Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms
نویسندگان
چکیده
منابع مشابه
Aubergine and piRNAs promote germline stem cell self‐renewal by repressing the proto‐oncogene Cbl
PIWI proteins play essential roles in germ cells and stem cell lineages. In Drosophila, Piwi is required in somatic niche cells and germline stem cells (GSCs) to support GSC self-renewal and differentiation. Whether and how other PIWI proteins are involved in GSC biology remains unknown. Here, we show that Aubergine (Aub), another PIWI protein, is intrinsically required in GSCs for their self-r...
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ژورنال
عنوان ژورنال: Developmental Cell
سال: 2017
ISSN: 1534-5807
DOI: 10.1016/j.devcel.2017.03.023